The Wound Healing Potential of 2,3 Dimethylquinoxaline Hydrogel in Rat Excisional Wound Model

Background: 2,3-dimethylquinoxaline (DMQ) is a naturally occurring compound with documented antifungal activity. It showed also good in vitro physicochemical and pharmacokinetic characteristics.
 Methods: The wound healing activity of 1% DMQ hydrogel healthy adult male Wister rats were evaluated using the excision model. On day 7, mean percentage closure area was determined. animals sacrificed on 7 skin isolated for histology research assessment some inflammatory & oxidative markers, hydroxyproline tissue growth factor.
 Results Discussion: Almost complete observed after treatment 1 % Jell days. histological study confirmed marked attenuation wound-induced changes. There reduction TNF-α, IL-6 IL-β1 NF-κB. levels. These data suggest potential anti-inflammatory effect DMQ.
 Conclusion: has ability likely due to its mechanism. Further needed confirm these preliminary findings explore molecular mechanism